Help Sick Little Sister

[Dozamura (Easy Thrilling)] Akazukin | Little Red Riding Hood (Doguu ~Dozamura Guuwa~ Kuro Ch.1) [English] [desudesu]

Pink ni Pop, Purin ni Pie (My Little Pony: Friendship Is Magic

(C74) [Sakuranbo Little (Kanbayashi Chiko)] Otonya no Jikan (Kodomo no Jikan)

Oshikake Ane | The Uninvited Stepsister

[Sena Youtarou] Imouto wa Shouganai!? | Sisters: It can be helped!? [English]

[Shinobu Tanei] Imouto Shojo Gensou | Little Stepsister Fantasy Virgin Ch. 1-9 [English] {Tadanohito}

[Yuizaki Kazuya] Yutorikei Imouto no Moe Zokusei ga Kote Kote Sugiru | My Little Sister is Too Damn Moe (Kinshin Sister Lovers ~ Jisshi to Jitsumai wa Chou Inranhen~) [English] [PSYN]

I Can't Handle My Former Bookworm Little Sister Now That She's a Slut! 2

Imouto no Nukumori | A Little Sister's warmth

[Mizone] Imouto to Hajimeru Kuromajutsu Gishiki | My Little Sister and her First Black Magic Ritual (COMIC Anthology QooPA Vol. 07) [English] [PSYN] [Digital]

(COMIC1☆5) [Number2 (Takuji)] Ore no Imouto to, Imouto no Tomodachi ni Motto Nama de Nakadashi suru. | I'll Cum Inside My Little Sister, and Her Friends Too (Ore no Imouto ga Konna ni Kawaii Wake ga Nai) [English] [Belldandy100] [Decensored]

When I Enter the Bathtub with my Little Sister | Imouto to Ofuro ni Haittara

(C78) [PTD (Tatsuhiko)] Wafukan (Little Busters!) [English] {Lunatic Translations}

Imouto no Otetsudai 6 | Little Sister Helper 6

My Big Brother Was Making a “Little Sister Observation Record,” So I Pretended to Have Zero Sexual Knowledge and All Sorts of Things Were Done to Me

[Shinobu Tanei] Little Stepsister Love Space Ch. 1 [English] {Tadanohito}

[Maeshima Ryou] Seijinshiki Gokko｜Make Believe Coming-of-Age Ceremony [English] [5 a.m. + Rin]

(Reitaisai 9) [Little Hamlet (Ra Kii)] Komeiji Satori no Soushitsu (Touhou Project)

(CR32) [Imomuya Honpo (Azuma Yuki)] Oniisama e... 4.5 Sister Princess "Sakuya" Book No.8 (Sister Princess)

[Kouzuki Rio] Imouto Saimin Choukyou Manual | Little Sister Hypnosis Training Manual Ch. 1 [English] {desudesu}

[Akatsuki Katsuie] Cool na Anoko no Shohouyaku | A Cool Little-Girl's Prescription-Drugs (COMIC LO 2018-04) [English] {Mistvern} [Digital]

(C84) [Sexual Khorosho (Lasto)] Omoi Kitte Imoto to Onnayu ni Haitte Mita | I went to the women's bath with my little sister [English] [ATF]

(C83) [Hanyan. (Nekomimi Kanon)] Kanryou Harem Keikaku Imouto Tengoku | Harem Plan Complete - Little Sister Heaven (To LOVE-Ru) [English] [Tigoris Translates]

Gehema Brother and Sister

Ore no Otouto ga Konna ni Kawaii Wake ga Nai | My Little Brother Can't be this Cute!

Business-like na Imouto | Entrepreneurial Little Sister

Imouto > Nii | Little Sister > Big Brother 1-3

Little Red (Akazukin Cha Cha)

[Power Slide (Uttorikun)] GO-SICKNESS (Gosick) [Digital]

[Anthology] LQ -Little Queen- Vol. 6 [Digital]

[Shinchara (YO-JIN)] BindLB5 (Clannad, Little Busters!) [Digital]

(C60) [HarthNir (Misakura Nankotsu)] Binzume Sisters 1-B (Guilty Gear, Sister Princess) [decensored]

[Joibo no Juunin] Akko ga Waruin dakara! (Little Witch Academia)

[Kanro Ame] Imouto Culture Shock! | Little Sister Culture Shock (Comic LO 2014-11) [English] [5 a.m.]

Bon Appetite!

Illya Imouto Onahole Kaihatsu Choukyou | Illya Little Sister Onahole Development Training

[TIES (Takei Ooki)] Onegai! FireSisters -Soushuuhen- (Bakemonogatari)

(C74) [Tennenseki (Suzuri)] Bokura no Shuugaku Ryokou (Little Busters!)

Imouto wa Sickness no Omake

[18 monkeys (Inono)] Meganekko no Imouto to Kindan no aa... uu... (Meganekko Little Sister & Forbidden AAH) [English] {SaHa}

[Little Mermaid] Tokeizaka no Miboujin (Maison Ikkoku)

(COMIC1☆6) [Korisuya (Korisu)] LITTLE WORLD

Yuuwaku・Imouto #3 Omocha Asobi | Little Sister Temptation #3 Playing with Toys

(C80) [Takanaedoko (Takanae Kyourin)] Imouto no Otetsudai | Little Sister's Helper [English] =Team Vanilla=

(C91) [Little Hamlet (Kiira)] Komeiji Satori no Classmate to Hokentaiiku (Touhou Project) [Chinese] [CE幻想夏结社]

(C73) [ARESTICA (Ariko Youichi)] Cherryade. (Little Busters!)

[Isawa Nohri] Ah! Little Flower [English] {Mistvern}

Kanryou Harem Keikaku Imouto Tengoku ｜ Harem Plan Complete - Little Sister Heaven

[RPG Company 2 (Yoriu Mushi)] R Shitei Ki ~Irumi to Hiroki~ | R-Shitei Play 1 - Little Night Crawling [English] [Digital]

Imouto no Otetsudai 7 | Little Sister Helper 7 {Hennojin}

(C89) [Little Hamlet (Kiira)] Komeiji Shimai no Futari Ecchi (Touhou Project)

[PiT (Natsuki Shuri)] SisterComplex [Digital]

[Jiyu2] - Cute Rabbit-san (eng)

(COMITIA119) [Littleollie (Deburasu)] Uchi no Imouto wa Kotowaranai | My Little Sister Doesn't Refuse Me [English] [ATF]

(C59) [Studio BIG-X (Arino Hiroshi)] Mousou Mini Theater 6 (Cardcaptor Sakura, Sister Princess)

[Aa Doushiyou (Pi-ko)] Ore no Imouto Tachi ga Hatsujouki na Wakega nai | There's No Way My Little Sister And Her Friend Are In Heat! (Ore no Imouto ga Konna ni Kawaii Wake ga Nai) [English] [Zettai Ryouiki] [Decensored] [Digital]

[Horitomo] Gimai Sensei Slime Momo-chan | Stepsister Teacher Slimy Momo (COMIC Unreal 2017-06 Vol. 67) [English] =Dark Mac + CW= [Digital]

[Ohnuma Hiroshi] Chibikko-tachi wa Natsu no Nioi | Little Children Smell of Summer [English] {Mistvern}

(C94) [squeezecandyheaven (Ichihaya)] Imouto to Sex Suru nante Kimochi Warui | Having Sex With Your Little Sister? That's Gross! [English] [sneikkimies]

[Naokame] S&M ~Okuchi de Tokete Asoko demo Tokeru (COMIC L.Q.M ~Little Queen Mount~ Vol. 1) [Chinese] [黑条汉化]

(Bokura no Love Live! 13) [Sweet Pea (Ooshima Tomo)] Kurosawa Shimai no Katei no Jijou | State of Affairs in The Kurosawa Sister’s Family Home (Love Live! Sunshine!!) [English]

A Little Incest [English] [Rewrite] [olddog51]

[Mizuyoukan] My Little Sister (Koniro Maid-san Chapter 9) [ENG] [Yoroshii]

Hito wa Mikake ni | Judge a person by their looks

[Ohnuma Hiroshi] Imouto Catalog | Little Sister Catalog (Comic LO 2016-03) [English] {Mistvern}

Uiuishii Imouto | Naive Little SIster

(COMITIA119) [Littleollie (Deburasu)] Uchi no Imouto wa Kotowaranai [Chinese] [山樱汉化]

[Yuzuki N Dash] Imouto Lip | Little Sister Lip 1-2 [English] [woootskie]

[Anthology] Little Girl Strike Vol. 6

[Porori] My First Time is with.... My Little Sister?! Ch.18

[Zat] しままんまんが (My Little Pony: Equestria Girls)

(C83) [Navy Blue (Kagura Nanaki)] Futaki Kanata no Ura Jouji (Little Busters!)

[Hadairozanmai (Mitei)] Imouto to Ofuro ni Haittara | When I Enter the Bathtub with my Little Sister [English] [Degenerate_X] [Digital]

(SC2018 Autumn) [squeezecandyheaven (Ichihaya)] Imouto wa Tashizan ga Dekinai + Omake | My Little Sister Can't Do Basic Addition + Bonus Story [English] [S;M]

The cute little sister gets mindbroken by the savage and gross elder brother's evil hands!

(C99) [Little Hamlet (Kiira)] Ikigao Miraretai Mi-ya-chan

(COMIC1☆14) [squeezecandyheaven (Ichihaya)] Imouto wa Genius | My Little Sister Is a Genius [English] {Doujins.com}

[Magukappu (Magukappu)] Dai Akko (Little Witch Academia) [English]

(Reitaisai 11) [Little Hamlet (Kiira)] Komeiji Satori A~shitai Ko~shitai (Touhou Project) [English]

(C89) [Takanaedoko (Takanae Kyourin)] Imouto no Otetsudai 6 | Little Sister Helper 6 [English] {Hennojin}

(C88) [Mekabu Fighter (Uirou)] Mekabu Witch Academia (Little Witch Academia) [Sample]

(C80) [Magudara Kaihou Doumei (Tsukuyomi Sazin)] Ore no Imouto ga Konna ni Saimin ni Kakaru Wake ga Nai | My Little Sister Can't Be Mind-Controlled Like This (Ore no Imouto ga Konna ni Kawaii Wake ga Nai) [English] [LWB + Trinity Translations Team]

(C53) [Cu-little2 (Betty, MAGI, Mimikaki)] Cu-Little Bakanya～ (Final Fantasy VII, Vampire Savior / Darkstalkers)

Zenryaku, Imouto ga Maid ni Narimashite | My Little Sister Has Become a Maid

Imouto ni Saimin Kakete Asobu Hon | A Book Of Playing With The Little Sister By Hypnotising Her

(SC46) [TIES (Takei Ooki)] Onegai! FireSisters★ (Bakemonogatari) [English] [Trinity Translations Team + Team Vanilla]

Kasou Douwa wa Kiken ga Ippai!?Chimamire no warui ko zenpen

(C73) [Hiyotama Goten (Nagase Yutaka)] Sisters File (Sister Princess)

Our Sweetback!!

[Shiina Nami] Aru Shimai Ai no Katachi | A Form of Sisterly Love (Tabete wa Ikenai 2) [English] [Digital]

(C92) [Fuyunonchi (Fuyuno Mikan)] Little sister with grande everyday 2 [English] [H-Konbini]

(C87) [Little Hamlet (Kiira)] Hajimete no Nyuukyo (Kantai Collection -KanColle-)

[Porori] My First Time is with.... My Little Sister?! Ch.23

[Yukiu Con] Boku no Imouto wa Kawaii! | My Little Sister is So Cute! (COMIC RiN 2011-01) [English]

(C92) [TIES (Takei Ooki)] COCOLOGIC [Chinese] [无毒汉化组]

Doujin Shoujo Monogatari

(C53) [Cu-little2 (Beti, MAGI, Mimikaki)] Cu-Little Bakanya~ (Final Fantasy VII, Darkstalkers)

[Naokame] S&M ~Okuchi de Tokete Asoko de mo Tokeru~ (COMIC L.Q.M ~Little Queen Mount~ Vol. 1) [Decensored]

(C93) [Mothman (henreader)] Imouto ni Kareshi ga Dekita toka Chotto Imi ga Wakaranai desu. | Wait, what do you mean my little sister got a boyfriend? [English] [ATF]

(C89) [Little Hamlet (Kiira)] Komeiji Shimai no Futari Ecchi (Touhou Project)

[Little mantis (Kuloamaki)] Aishi~Play | 愛的玩耍 [Chinese] [臭鼬娘漢化組] [Digital]

(C51) [Cu-little2 (Beti, MAGI)] Cu-Little!! (Various)

[Tanabe Kyou] Imouto no Iu Toori | As My Little Sister Says (COMIC Megastore Alpha 2015-06) [English] [Facedesk]

(COMITIA119) [Littleollie (Deburasu)] Uchi no Imouto wa Kotowaranai

(C91) [Wancho-ke (Wancho)] Imouto wa Minna Onii-chan ga Suki! 4 | All little sisters love their big brothers! 4 [English] [ATF]

(Tora Matsuri 2010) [Raijinkai (Haruki Genia)] Oreimo Binetsu Tyuihou 1 | Little Sister Fever Warning 1 (Ore no Imouto ga Konna ni Kawaii Wake ga Nai) [English] =Team Vanilla=